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Scientists Create Baby Mice from Mouse Stem Cells

From News-Medical-Net

In groundbreaking research scientists from China have for the first
time created baby mice by using powerful stem cells from adult mouse

Embryonic stem cells, taken from 'days-old' embryos, are
able to develop into any cell type and, in mice, can be implanted into
a mother's womb to create living mouse pups - they are the body's
master cells, giving rise to all the tissues, organs and blood and are
considered the most powerful kind of stem cells.

The research
was carried out by two separate teams of scientists in China and the
breakthrough was made using re-programmed adult stem cells which
created 37 stem cell lines, and of these, three generated live births.

Stem Cell experts say it is the first time "induced pluripotent stem
cells" (IPS cells) have been used to make an entire mouse using mouse
fibroblasts, which are cells found in connective tissue in the skin.

the research the adult IPS stem cells were taken from the tail or skin
of a mouse - the researchers introduced genes into the cells to
reprogram them to become the equivalent of an embryonic stem cell.

author of one of the studies which is published in Nature, Professor
Fanyi Zeng from the Shanghai Stem Cell Institute, says her team
produced 27 mice using IPS cells and the oldest mice are nine months
old and while some are showing abnormalities, they are reproducing.

Fanyi says this is the strictest test that can possibly be done to show
that a cell is capable of forming every cell in the body and the
research demonstrates how safe and stable these cell types are over the
long term.

Professor Fanyi says the research offers hope for future therapeutic intervention using a patients' own re-programmed cells.

Andrew Laslett from the Human Embryonic Stem Cell Technology at the
Australian Stem Cell Centre in Melbourne, who works with both IPS cells
and embryonic stem cells, says the results have reinforced their work -
he says though every new breakthrough in such adult stem cell
technology inevitably evokes calls for work with human embryos to be
abandoned, that action would be a mistake.

Dr. Laslett believes
IPS cell technology still has a very long way to go for it to be
considered safe and the only way to validate the IPS cells is to
directly compare them to human embryonic technology.

In theory
the research could mean that it is possible to clone someone using
ordinary connective tissue cells found on the person's skin, but
scientists say they are confident that their research will be used to
understand the root causes of disease and lead to viable treatments and
cures of human afflictions.

The research papers are published in the journals Nature and Cell Stem Cell.


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