Update on Publications by Greek et al - Opposing Views

Update on Publications by Greek et al

Publish date:

2012 was a busy year for me and I think I failed to inform everyone of some recent publications.[1-4]

I completed two book chapters that were published late 2012 / early 2013. Animal Models of Cancer in Light of Evolutionary Biology and Complexity Science [1] addresses animal models of cancer while Animal Models in Drug Development [2] expands on what I have written in the past on this topic.

Dr Andre Menache and I published Systematic Reviews Of Animal Models: Methodology Versus Epistemology [3] in Int J Med Sci this year. This article addresses why systematic reviews of modalities with no scientific basis are not helpful in determining whether the modality should be used. I benefitted in writing this article from essays published at Science-Based Medicine and Respectful Insolence.

Monozygotic twins: identical in name only [4] is a letter by Mark Rice, MD and myself in response to an article examining the response of monozygotic versus dizygotic twins. This letter has nothing to do with animal models, at least at first glance. We address the differences between monozygotic twins, which is a point that is relevant when discussing what can be expected when attempting to model one complex evolved system with another. (For a partial list of other, recent publications, see here.)

Publications such as these, in peer-reviewed journals and books, substantiates our case. The fact that the vested interest groups refuse to address the points made in these publications, choosing instead to present straw man arguments, also supports our position. Sadly, the fact that physicians, veterinarians, and scientists that support our position privately refuse to do so publicly means humans will continue to die because of animal modeling.


1.         Greek, R (2013) Animal Models of Cancer in Light of Evolutionary Biology and Complexity Science. In: The Research and Biology of Cancer. iConcept Press, Hong Kong 978-14775549-9-9. http://www.iconceptpress.com/www/site/papers.webView.php?publicationID=BK030A

2.         Greek, R (2013) Animal Models in Drug Development. In: Gowder, S (ed) New Insights into Toxicity and Drug Testing. InTech, Manhattan, p 124-152. 980-953-307-844-6. http://www.intechopen.com/books/new-insights-into-toxicity-and-drug-testing/animal-models-in-drug-development

3.         Greek, R, A Menache (2013) Systematic Reviews of Animal Models: Methodology versus Epistemology. Int J Med Sci 10:206-221. 10.7150/ijms.5529. http://www.medsci.org/v10p0206.htm.

4.         Greek, R, MJ Rice (2013) Monozygotic twins: identical in name only. Anesthesiology 118:230. 10.1097/ALN.0b013e318278c785. http://journals.lww.com/anesthesiology/Fulltext/2013/01000/Monozygotic_Twins___Identical_in_Name_Only.48.aspx.


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