The card, which has been rumored for several weeks now, will take place from Las Vegas and the MGM Grand Garden Arena. Several other bouts have been set for the card including Jason "Mayhem" Miller vs. C.B. Dollaway and Edson Barboza against Evan Dunham.
Dos Santos won the title from Cain Velasquez last year, earning a first round knockout. He is 14-1 in his MMA career and a perfect 8-0 in the UFC.
Overeem (36-11) earned the shot with a victory over Brock Lesnar in his UFC debut. "The Reem" is a former Strikeforce heavyweight champion.
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