Should Medical Marijuana be Federally Legalized?

Should Medical Marijuana be Federally Legalized?

Millions of Americans take prescription drugs to treat a plethora of illnesses and symptoms, but not all drugs are created equal. The question of whether or not to consider marijuana a viable medical treatment remains a hot button issue. In states like California, medical marijuana clubs have flourished despite their federal illegality. Should the federal government allow states to make their own decisions, or is marijuana nothing more than a dangerous narcotic?

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Dr Voth

Marijuana is a Poor Excuse for a Medicine

Dr. Eric Voth

M.D., FACP

Below are some of the disorders that marijuana advocates contend that marijuana will help relieve. The subsequent statements concisely summarize the state of the medical literature.

Nausea from cancer chemotherapy: Neither marijuana nor cannabinoids have been evaluated against the newer effective anti-nausea medicine such as Zofran or Kytril. Marijuana and pure THC are only approximately as effective as the ancient medication compazine. The newer medicines have far fewer side effects than cannabinoids.

Glaucoma: There is no evidence that cannabinoids slow the progression of optic nerve deterioration, blindness, nor any element of the disease. Marijuana would need to be used several times daily, and has far more toxicity than available prescribed medications.

Appetite in AIDS wasting or cancer: While cannabinoids and cannabis increase appetite, it appears that only body fat is increased. Healthy nutrition would need to increase lean body mass in order for the weight gain to be beneficial to the subject.

Pain: While cannabinoids may have some benefit in modulating pain, they are no more effective than currently available medicine called neuroleptics or opiate-based pain medication. They also have a very small therapeutic window, so higher doses can actually increase pain.

Spasticity in Multiple sclerosis: Cannabinoids can reduce some muscle spasticity, they impair stable gait (ability to walk). They are generally more toxic than available MS medicines.

Depression and anxiety: There is no compelling evidence that marijuana helps these disorders. In fact, marijuana is a cause of psychosis, enhances anxiety in some people, and higher doses actually cause depression. It also causes dependence.

Headaches and Menstrual cramps: Marijuana is dangerous in women of child-bearing age because of toxic effects on the fetus. There is also no clear evidence that marijuana actually benefits these disorders any more than sedatives, and perhaps only from the intoxicating properties.

Evidence

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Are Cannabinoids an Effective and Safe Treatment Option?
Campbell FA, Tramer MR, Carroll D, Reynolds DJ, Moore RA, McQuay HJ. Are Cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. British Journal of Medicine 2001;323: 13-16 [ systematic review of the available literature on cannabinoids and pain. Concluded that cannabinoids are no more effective than codeine in controlling pain and have depressant effects that limit usefulness. Should not be used in acute pain. Widespread introduction into clinical pain practice is undesirable. ]
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Treatment of End-Stage Open-Angle Glaucoma
Flash AJ. Delta-9-tetrahydrocannabinol (THC) in the treatment of end-stage open-angle glaucoma. Trans Am Ophthalmo Soc 2002;215-222. [a study of ophthalmologists were treated with either oral THC or inhaled marijuana in addition to their regimen. Only nine patients were ultimately enrolled. Although there was an initial decrease in intraocular pressure, the goal was met in only 4 of 9 patients, and the decreases in pressure were not sustained. All patients chose to discontinue treatment within 1 to 9 months for various reasons. ]
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Combination Therapy for Cancer-Associated Anorexia
Jatai A, Windschitl HE, Loprinzi CL, Sloan JA, Dakhil SR, Mailliard JA, Pundaleeka Sarode, Kardinal CG, Krook JE, Novotny PJ, Christensen B. Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: A North Central Cancer Treatment Group Study. Journal of Clinical Oncology, 2002;20:567-573 (megestrol provided superior anorexia palliation in advanced cancer pts.)
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Safety, Tolerability, and Efficacy of Orally Administered Cannabinoids
Kellestein J, Hoogervors ELJ, Kalkers NF, van Loenen AC, Staats PGM, Gorter RW, Uitdehaag BMJ, Polman CH. Safety, tolerability, and efficacy of orally administered cannabinoids... Neurology 2002;58:1404-1407 [Dutch evaluation of utility of cannabionoids. Used plant extract or marinol. Neither helped and both worsened participants' global impression of spasticity. Adverse events were more common with the plant-extract preparation. This is the largest and longest duration study to date.]
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Cannabinoids for Control of Chemotherapy Induced Nausea
Tramer MR, Carroll D, Campbell FA. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. BMJ 2001;323:16-21. [Evaluated the state of the research on cannabinoids and concluded that in selected pts may be useful as mood enhancing agents, but serious adverse side effects even when taken short term will likely limit their usefulness. They also said, "These results should make us think hard about the ethics of clinical trials of cannabinoids when safe and effective alternatives are known to exist and when efficacy of cannabinoids is known to be marginal." ]
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Effects of Smoked Cannabis on Capsaicin-Induced Pain and Hyperalgesia
Wallace M, Schulteis G, Atkinson JH, Wolfson T, Lazzaretto D, Bentley H, Gouaux B, Abramson I. Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. Anesthesiology. 2007;107:785-96. (5 minutes after use, no effect at any dose. 45 minutes-decrease in pain at medium dose, increase in pain at high dose. Concentration was 0,2,4,8% THC. May be a component at high doses that actually increases the perception of pain. This means that there is a narrow therapeutic window of efficacy. “Cannot advocate a place for using cannabis in the treatment armamentarium at this time.” Smoking and Psychotropic side effects are concerns.)
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Cultivating Science, Weeding Out the Fiction
Wingerchuk D. Cannabis for medical purposes: cultivating science, weeding out the fiction. Lancet 2004:364:315-316 (From Mayos, quotes that only 43% of the patients with epilepsy were using the marijuana, 2/3 MS claimed relief. Little scientific evidence of its effectiveness and no controlled studies support use for epilepsy, hazards of mood disorders and cognitive dysfunction should be considered.)
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